AutomedicationFrancoV1, Main, Exploration, bibRecord, 000780

Stability, reliability, and validity of the THINC-it screening tool for cognitive impairment in depression: A psychometric exploration in healthy volunteers.

Identifieur interne : 000780 ( Main/Exploration ); précédent : 000779; suivant : 000781

Stability, reliability, and validity of the THINC-it screening tool for cognitive impairment in depression: A psychometric exploration in healthy volunteers.

Auteurs : John E. Harrison [Pays-Bas, Royaume-Uni] ; Harry Barry [Irlande (pays)] ; Bernhard T. Baune [Australie] ; Michael W. Best [Canada] ; Christopher R. Bowie [Canada] ; Danielle S. Cha [Canada] ; Larry Culpepper [États-Unis] ; Philippe Fossati [France] ; Tracy L. Greer [États-Unis] ; Catherine Harmer [Royaume-Uni] ; Esther Klag [Royaume-Uni] ; Raymond W. Lam [Canada] ; Yena Lee [Canada] ; Rodrigo B. Mansur [Canada] ; Hans-Ulrich Wittchen [Allemagne] ; Roger S. Mcintyre [Canada]

Source :

International journal of methods in psychiatric research [ 1557-0657 ] ; 2018.

RBID : pubmed:30088298

Descripteurs français

KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Dysfonctionnement cognitif (diagnostic), Dysfonctionnement cognitif (étiologie), Femelle (MeSH), Humains (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Psychométrie (méthodes), Reproductibilité des résultats (MeSH), Tests neuropsychologiques (normes), Trouble dépressif majeur (complications).
MESH :
- diagnostic : Dysfonctionnement cognitif.
- méthodes : Psychométrie.
- normes : Tests neuropsychologiques.
- étiologie : Dysfonctionnement cognitif.
- complications : Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, Reproductibilité des résultats, Trouble dépressif majeur.

English descriptors

KwdEn :
- Adult (MeSH), Cognitive Dysfunction (diagnosis), Cognitive Dysfunction (etiology), Depressive Disorder, Major (complications), Female (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Neuropsychological Tests (standards), Psychometrics (methods), Reproducibility of Results (MeSH), Young Adult (MeSH).
MESH :
- complications : Depressive Disorder, Major.
- diagnosis : Cognitive Dysfunction.
- etiology : Cognitive Dysfunction.
- methods : Psychometrics.
- standards : Neuropsychological Tests.
- Adult, Female, Humans, Male, Middle Aged, Reproducibility of Results, Young Adult.

Abstract

OBJECTIVES

There is a need for a brief, reliable, valid, and sensitive assessment tool for screening cognitive deficits in patients with Major Depressive Disorders. This paper examines the psychometric characteristics of THINC-it, a cognitive assessment tool composed of four objective measures of cognition and a self-rated assessment, in subjects without mental disorders.

METHODS

N = 100 healthy controls with no current or past history of depression were tested on four sequential assessments to examine temporal stability, reliability, and convergent validity of the THINC-it tests. We examined temporal reliability across 1 week and stability via three consecutive assessments. Consistency of assessment by the study rater (intrarater reliability) was calculated using the data from the second and third of these consecutive assessments.

RESULTS

Test-retest reliability correlations varied between Pearson's r = 0.75 and 0.8. Intrarater reliability between 0.7 and 0.93. Stability for the primary measure for each test yielded within-subject standard deviation values between 5.9 and 11.23 for accuracy measures and 0.735 and 17.3 seconds for latency measures. Convergent validity for three tasks was in the acceptable range, but low for the Symbol Check task.

CONCLUSIONS

Analysis shows high levels of reliability and stability. Levels of convergent validity were modest but acceptable in the case of all but one test.

DOI: 10.1002/mpr.1736
PubMed: 30088298
PubMed Central: PMC6174931

Affiliations:

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Le document en format XML

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<author><name sortKey="Lee, Yena" sort="Lee, Yena" uniqKey="Lee Y" first="Yena" last="Lee">Yena Lee</name>
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<author><name sortKey="Mcintyre, Roger S" sort="Mcintyre, Roger S" uniqKey="Mcintyre R" first="Roger S" last="Mcintyre">Roger S. Mcintyre</name>
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<affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</nlm:affiliation>
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<wicri:regionArea>Department of Psychiatry, University of Toronto, Toronto, ON</wicri:regionArea>
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<affiliation wicri:level="4"><nlm:affiliation>Department of Pharmacology, University of Toronto, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Pharmacology, University of Toronto, Toronto, ON</wicri:regionArea>
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<author><name sortKey="Best, Michael W" sort="Best, Michael W" uniqKey="Best M" first="Michael W" last="Best">Michael W. Best</name>
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<author><name sortKey="Bowie, Christopher R" sort="Bowie, Christopher R" uniqKey="Bowie C" first="Christopher R" last="Bowie">Christopher R. Bowie</name>
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<wicri:noRegion>ON</wicri:noRegion>
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<author><name sortKey="Cha, Danielle S" sort="Cha, Danielle S" uniqKey="Cha D" first="Danielle S" last="Cha">Danielle S. Cha</name>
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<country xml:lang="fr">Canada</country>
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<wicri:noRegion>ON</wicri:noRegion>
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<country xml:lang="fr">États-Unis</country>
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</placeName>
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<author><name sortKey="Fossati, Philippe" sort="Fossati, Philippe" uniqKey="Fossati P" first="Philippe" last="Fossati">Philippe Fossati</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, APHP, Institut du cerveau et de la moelle (ICM)-Hôpital Pitié Salpétrière, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Greer, Tracy L" sort="Greer, Tracy L" uniqKey="Greer T" first="Tracy L" last="Greer">Tracy L. Greer</name>
<affiliation wicri:level="2"><nlm:affiliation>Centre for Depression Research and Clinical Care, Department of Psychiatry, University of Texas, Dallas, Texas, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Centre for Depression Research and Clinical Care, Department of Psychiatry, University of Texas, Dallas, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harmer, Catherine" sort="Harmer, Catherine" uniqKey="Harmer C" first="Catherine" last="Harmer">Catherine Harmer</name>
<affiliation wicri:level="3"><nlm:affiliation>Cognitive Neuroscience, Department of Psychiatry, Oxford University, Oxford, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cognitive Neuroscience, Department of Psychiatry, Oxford University, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klag, Esther" sort="Klag, Esther" uniqKey="Klag E" first="Esther" last="Klag">Esther Klag</name>
<affiliation wicri:level="3"><nlm:affiliation>Clinical Psychologist, Rehabilitation Neuropsychologist, Psychotherapist, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Psychologist, Rehabilitation Neuropsychologist, Psychotherapist, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lam, Raymond W" sort="Lam, Raymond W" uniqKey="Lam R" first="Raymond W" last="Lam">Raymond W. Lam</name>
<affiliation wicri:level="1"><nlm:affiliation>BC Leadership Chair in Depression Research, Vancouver, BC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>BC Leadership Chair in Depression Research, Vancouver, BC</wicri:regionArea>
<wicri:noRegion>BC</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry, University of British Columbia, Vancouver, BC</wicri:regionArea>
<orgName type="university">Université de la Colombie-Britannique</orgName>
<placeName><settlement type="city">Vancouver</settlement>
<region type="state">Colombie-Britannique </region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Djavad Mowafaghian Centre for Brain Health, Mood Disorders Centre, Vancouver, BC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Djavad Mowafaghian Centre for Brain Health, Mood Disorders Centre, Vancouver, BC</wicri:regionArea>
<wicri:noRegion>BC</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Network for Mood and Anxiety Treatments (CANMAT), Vancouver, BC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Network for Mood and Anxiety Treatments (CANMAT), Vancouver, BC</wicri:regionArea>
<wicri:noRegion>BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Yena" sort="Lee, Yena" uniqKey="Lee Y" first="Yena" last="Lee">Yena Lee</name>
<affiliation wicri:level="1"><nlm:affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Medical Science, University of Toronto, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Institute of Medical Science, University of Toronto, Toronto, ON</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mansur, Rodrigo B" sort="Mansur, Rodrigo B" uniqKey="Mansur R" first="Rodrigo B" last="Mansur">Rodrigo B. Mansur</name>
<affiliation wicri:level="1"><nlm:affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Canadian Network for Mood and Anxiety Treatments (CANMAT), Vancouver, BC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Canadian Network for Mood and Anxiety Treatments (CANMAT), Vancouver, BC</wicri:regionArea>
<wicri:noRegion>BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wittchen, Hans Ulrich" sort="Wittchen, Hans Ulrich" uniqKey="Wittchen H" first="Hans-Ulrich" last="Wittchen">Hans-Ulrich Wittchen</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Clinical Psychology and Psychotherapy and Centre of Clinical Epidemiology and Longitudinal Studies, (CELOS), Technische Universität Dresden, Dresden, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Clinical Psychology and Psychotherapy and Centre of Clinical Epidemiology and Longitudinal Studies, (CELOS), Technische Universität Dresden, Dresden</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Dresde</region>
<settlement type="city">Dresde</settlement>
</placeName>
<orgName type="university">Université technique de Dresde</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Clinical Psychology and Psychotherapy MPCB, Dresden, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinical Psychology and Psychotherapy MPCB, Dresden</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Dresde</region>
<settlement type="city">Dresde</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcintyre, Roger S" sort="Mcintyre, Roger S" uniqKey="Mcintyre R" first="Roger S" last="Mcintyre">Roger S. Mcintyre</name>
<affiliation wicri:level="1"><nlm:affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Medical Science, University of Toronto, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Institute of Medical Science, University of Toronto, Toronto, ON</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry, University of Toronto, Toronto, ON</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Brain and Cognition Discovery Foundation (BCDF), Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Brain and Cognition Discovery Foundation (BCDF), Toronto, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pharmacology, University of Toronto, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Pharmacology, University of Toronto, Toronto, ON</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">International journal of methods in psychiatric research</title>
<idno type="eISSN">1557-0657</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Cognitive Dysfunction (diagnosis)</term>
<term>Cognitive Dysfunction (etiology)</term>
<term>Depressive Disorder, Major (complications)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Neuropsychological Tests (standards)</term>
<term>Psychometrics (methods)</term>
<term>Reproducibility of Results (MeSH)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Dysfonctionnement cognitif (diagnostic)</term>
<term>Dysfonctionnement cognitif (étiologie)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Psychométrie (méthodes)</term>
<term>Reproductibilité des résultats (MeSH)</term>
<term>Tests neuropsychologiques (normes)</term>
<term>Trouble dépressif majeur (complications)</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Depressive Disorder, Major</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognitive Dysfunction</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Dysfonctionnement cognitif</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognitive Dysfunction</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Psychometrics</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Psychométrie</term>
</keywords>
<keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Tests neuropsychologiques</term>
</keywords>
<keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Neuropsychological Tests</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Dysfonctionnement cognitif</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Reproducibility of Results</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Reproductibilité des résultats</term>
<term>Trouble dépressif majeur</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>There is a need for a brief, reliable, valid, and sensitive assessment tool for screening cognitive deficits in patients with Major Depressive Disorders. This paper examines the psychometric characteristics of THINC-it, a cognitive assessment tool composed of four objective measures of cognition and a self-rated assessment, in subjects without mental disorders.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>N = 100 healthy controls with no current or past history of depression were tested on four sequential assessments to examine temporal stability, reliability, and convergent validity of the THINC-it tests. We examined temporal reliability across 1 week and stability via three consecutive assessments. Consistency of assessment by the study rater (intrarater reliability) was calculated using the data from the second and third of these consecutive assessments.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Test-retest reliability correlations varied between Pearson's r = 0.75 and 0.8. Intrarater reliability between 0.7 and 0.93. Stability for the primary measure for each test yielded within-subject standard deviation values between 5.9 and 11.23 for accuracy measures and 0.735 and 17.3 seconds for latency measures. Convergent validity for three tasks was in the acceptable range, but low for the Symbol Check task.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Analysis shows high levels of reliability and stability. Levels of convergent validity were modest but acceptable in the case of all but one test.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30088298</PMID>
<DateCompleted><Year>2019</Year>
<Month>07</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2021</Year>
<Month>01</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1557-0657</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>27</Volume>
<Issue>3</Issue>
<PubDate><Year>2018</Year>
<Month>09</Month>
</PubDate>
</JournalIssue>
<Title>International journal of methods in psychiatric research</Title>
<ISOAbbreviation>Int J Methods Psychiatr Res</ISOAbbreviation>
</Journal>
<ArticleTitle>Stability, reliability, and validity of the THINC-it screening tool for cognitive impairment in depression: A psychometric exploration in healthy volunteers.</ArticleTitle>
<Pagination><MedlinePgn>e1736</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mpr.1736</ELocationID>
<Abstract><AbstractText Label="OBJECTIVES">There is a need for a brief, reliable, valid, and sensitive assessment tool for screening cognitive deficits in patients with Major Depressive Disorders. This paper examines the psychometric characteristics of THINC-it, a cognitive assessment tool composed of four objective measures of cognition and a self-rated assessment, in subjects without mental disorders.</AbstractText>
<AbstractText Label="METHODS">N = 100 healthy controls with no current or past history of depression were tested on four sequential assessments to examine temporal stability, reliability, and convergent validity of the THINC-it tests. We examined temporal reliability across 1 week and stability via three consecutive assessments. Consistency of assessment by the study rater (intrarater reliability) was calculated using the data from the second and third of these consecutive assessments.</AbstractText>
<AbstractText Label="RESULTS">Test-retest reliability correlations varied between Pearson's r = 0.75 and 0.8. Intrarater reliability between 0.7 and 0.93. Stability for the primary measure for each test yielded within-subject standard deviation values between 5.9 and 11.23 for accuracy measures and 0.735 and 17.3 seconds for latency measures. Convergent validity for three tasks was in the acceptable range, but low for the Symbol Check task.</AbstractText>
<AbstractText Label="CONCLUSIONS">Analysis shows high levels of reliability and stability. Levels of convergent validity were modest but acceptable in the case of all but one test.</AbstractText>
<CopyrightInformation>© 2018 The Authors International Journal of Methods in Psychiatric Research Published by John Wiley & Sons, Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Harrison</LastName>
<ForeName>John E</ForeName>
<Initials>JE</Initials>
<Identifier Source="ORCID">0000-0002-0225-4923</Identifier>
<AffiliationInfo><Affiliation>Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Kilmington Common, Metis Cognition Ltd, Wiltshire, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barry</LastName>
<ForeName>Harry</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Stoneylane Clinic Drogheda, Co Louth, Ireland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baune</LastName>
<ForeName>Bernhard T</ForeName>
<Initials>BT</Initials>
<AffiliationInfo><Affiliation>Discipline of Psychiatry, University of Adelaide, Adelaide, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Best</LastName>
<ForeName>Michael W</ForeName>
<Initials>MW</Initials>
<AffiliationInfo><Affiliation>Department of Psychology, Queen's University, Kingston, ON, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bowie</LastName>
<ForeName>Christopher R</ForeName>
<Initials>CR</Initials>
<AffiliationInfo><Affiliation>Department of Psychology, Queen's University, Kingston, ON, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre for Addiction and Mental Health, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cha</LastName>
<ForeName>Danielle S</ForeName>
<Initials>DS</Initials>
<AffiliationInfo><Affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Culpepper</LastName>
<ForeName>Larry</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Family Medicine, Boston University, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fossati</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, APHP, Institut du cerveau et de la moelle (ICM)-Hôpital Pitié Salpétrière, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Greer</LastName>
<ForeName>Tracy L</ForeName>
<Initials>TL</Initials>
<AffiliationInfo><Affiliation>Centre for Depression Research and Clinical Care, Department of Psychiatry, University of Texas, Dallas, Texas, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Harmer</LastName>
<ForeName>Catherine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Cognitive Neuroscience, Department of Psychiatry, Oxford University, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Klag</LastName>
<ForeName>Esther</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Clinical Psychologist, Rehabilitation Neuropsychologist, Psychotherapist, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lam</LastName>
<ForeName>Raymond W</ForeName>
<Initials>RW</Initials>
<AffiliationInfo><Affiliation>BC Leadership Chair in Depression Research, Vancouver, BC, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Djavad Mowafaghian Centre for Brain Health, Mood Disorders Centre, Vancouver, BC, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Canadian Network for Mood and Anxiety Treatments (CANMAT), Vancouver, BC, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Yena</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Medical Science, University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mansur</LastName>
<ForeName>Rodrigo B</ForeName>
<Initials>RB</Initials>
<AffiliationInfo><Affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Canadian Network for Mood and Anxiety Treatments (CANMAT), Vancouver, BC, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wittchen</LastName>
<ForeName>Hans-Ulrich</ForeName>
<Initials>HU</Initials>
<AffiliationInfo><Affiliation>Institute of Clinical Psychology and Psychotherapy and Centre of Clinical Epidemiology and Longitudinal Studies, (CELOS), Technische Universität Dresden, Dresden, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Clinical Psychology and Psychotherapy MPCB, Dresden, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McIntyre</LastName>
<ForeName>Roger S</ForeName>
<Initials>RS</Initials>
<AffiliationInfo><Affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Medical Science, University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Brain and Cognition Discovery Foundation (BCDF), Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pharmacology, University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>08</Month>
<Day>07</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Int J Methods Psychiatr Res</MedlineTA>
<NlmUniqueID>9111433</NlmUniqueID>
<ISSNLinking>1049-8931</ISSNLinking>
</MedlineJournalInfo>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060825" MajorTopicYN="N">Cognitive Dysfunction</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003865" MajorTopicYN="N">Depressive Disorder, Major</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009483" MajorTopicYN="N">Neuropsychological Tests</DescriptorName>
<QualifierName UI="Q000592" MajorTopicYN="Y">standards</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011594" MajorTopicYN="N">Psychometrics</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">cognition</Keyword>
<Keyword MajorTopicYN="Y">depression</Keyword>
<Keyword MajorTopicYN="Y">memory</Keyword>
<Keyword MajorTopicYN="Y">neuropsychological</Keyword>
<Keyword MajorTopicYN="Y">screening</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>06</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>06</Month>
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Stability, reliability, and validity of the THINC-it screening tool for cognitive impairment in depression: A psychometric exploration in healthy volunteers.

Stability, reliability, and validity of the THINC-it screening tool for cognitive impairment in depression: A psychometric exploration in healthy volunteers.

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